Science News

The 1992 tearjerker Lorenzo’s Oil told the true story of one family’s struggle to save their son from X-linked adrenoleukodystrophy (ALD), a deadly degenerative brain disease. Unfortunately, over the ensuing years, the oil of the film’s title, a dietary supplement, has not panned out as the cure many people hoped it would be. Now a paper in the November 2009 issue of Science suggests that the long-sought cure may come from gene therapy--a famously hyped approach to treatment that tragically caused the death of a teenage experimental subject in 1999.

Since then, however, researchers have continued to cautiously pursue gene therapy for certain disorders with known genetic origins. ALD, for instance, is caused by mutations in a gene called ABCD1, leading to unusually high levels of a type of fatty acid that damages the material insulating some neurons. It affects about one in 20,000 six- to eight-year-old boys, leading to death before adolescence. The main treatment is still bone marrow transplantation: a risky procedure that relies on finding a suitable donor, explains Patrick Aubourg, a neurologist at France’s INSERM research institute.

The Other Brain: From Dementia to Schizophrenia, How New Discoveries about the Brain Are Revolutionizing Medicine and Science by R. Douglas Fields. [More]

Winds of Change I found it surprising that in “ A Path to Sustainable Energy by 2030 ,” Mark Z. Jacobson and Mark A. Delucchi do not mention the effects of the suggested energy sources on climate. The authors propose to absorb about six terawatts of energy from about 60 terawatts available in the wind, or about 10 percent of its total energy. Because the winds, at least near the U.S., usually flow around highs or lows, where the speed and related Coriolis force tend to maintain the pressure difference, I can easily envision that absorbing the energy will change the rate at which the pressure centers collapse. How this would change the weather, I do not know, but it must make a change to give us some of the energy. Possibly, the weather change would be an improvement, but as a believer in Murphy’s Law, I would be surprised. About 100 years ago dumping garbage into the ocean was justified because the oceans were infinite compared to the effect, so no one calculated how much was allowable. Let’s be smarter this time! Why not do the calculations before we cause more problems? [More]

MIAMI--In three months, hundreds of thousands of soccer fans are expected to descend on nine South African cities for the 2010 World Cup. But for so many visitors going to a country where more than 10 percent of the population is estimated to have HIV/AIDS, many public health experts are worried that the event will kick off a spike in transmission. South Africa, in turn, has responded by requesting one billion condoms for the year (many of which will be supplied by the U.K.)--more than twice as many as usual, the BBC noted . [More]